Endocrine Abstracts

Introduction: Incidental papillary thyroid carcinoma (PTC) in patients undergoing thyroidectomy for benign multinodular disease is a well-recognised finding. Its true prevalence remains uncertain and shows great variability between studies, ranging from 7–25%. Our purpose was to review the prevalence of PTC in thyroid glands removed for benign nodular disease at a Northern Portuguese tertiary hospital.Methods: From December 2012 to December 2014, th...

Background: The adrenal incidentalomas (AI), adrenal masses ≥10 mm in diameter incidentally detected, have increased their prevalence due to technological advances in imaging. The adrenalectomy is indicated in functioning adrenal tumors and in cases suspected of malignancy.Objectives: To analyze the characteristics of patients with AI and to evaluate the clinical outcome, in terms of evolution toward hypersecretion and significant growth, during fo...

Background: Community acquired pneumonia (CAP) is a common condition and a major cause of morbidity. Diabetes mellitus (DM) increases the risk and complications of infectious diseases. However, it is necessary to clarify if DM and glycemia at the time of presentation are prognostic factors in patients with CAP.Objectives: To evaluate the relationship between DM/glycemia at the time of presentation and complications, length of stay and mortality in patien...

Levothyroxine (L-T4) is the mainstay of treatment of hypothyroidism. Marked elevation of thyrotropin (TSH) in patients on high replacement doses is rare and can result from malabsorption, drug interaction or poor compliance. The levothyroxine absorption test is required to distinguish these causes and has proved to be safe. This test measures the serum free thyroxine (FT4) response to 1 mg of oral L-T4 over 4–24 h.Clinical cases: Case no 1: A 28-yea...

IntroductionThe toxic solitary thyroid nodule is a major cause of hyperthyroidism, especially in iodine-deprived regions. The most widely used therapy is iodine-131, which is effective in achieving normal thyroid function and reducing nodule dimensions, however, it may induce hypothyroidism. The aim of this study was to evaluate the outcomes of radioiodine therapy in patients with toxic solitary nodules and to determine predictive factors for the develop...

Introduction: Cyclic Cushing’s Syndrome is an uncommon disorder characterized by recurrent episodes of elevated cortisol levels, alternating with periods of normal cortisol secretion. These cycles of hypercortisolism can occur at regular or irregular intervals, ranging from days to years between episodes.Case presentation: A 57-year-old woman evaluated at the Endocrinology Outpatient Clinic because of symptoms of hypercortisolism with 18 months of e...

Introduction: Immunotherapy has demonstrated a key role in the current individualized treatment of multiple neoplasms, with adverse events related to the endocrine. Thyroid dysfunction is the most frequent reported endocrine event during treatment with pembrolizumab, being autoimmune diabetes an extremely rare adverse effect.Case Report: We present a case of a 72-year-old man with a progressing urothelial bladder carcinoma (stage IIIB), under treatment w...

Introduction: Bariatric surgery (BS) candidates display several nutritional deficiencies that can aggravate after surgery. Metabolic syndrome (MS) is a cluster of cardiovascular risk factors with several disturbed metabolic pathways. Therefore, individuals with MS submitted to BS are probably more prone to nutritional deficiencies.Objective: To evaluate the prevalence of nutritional deficiencies and eventual differences between BS candidates with and wit...

Background: Sleeve gastrectomy (SG) has effective results on weight loss, which should result from fat mass loss and efforts should be made to preserve lean mass. Few studies have evaluated body composition (BC) changes after SG for periods >2 years.Objective: To investigate the impact of SG on weight and BC, comparing by gender.Materials and methods: Retrospectively, databases of patients who underwent SG between 2011 and 2013...

Introduction: Gestational diabetes (GD) is associated with a significantly higher risk of perinatal complications. It has been suggested that third-trimester (3thT) foetal abdominal circumference (fAC) determination is an important predictor of macrossomia and large for gestational age (LGA).Aims: The purpose of this study was to evaluate the association between the 3thT fAC percentile with birthweight (BW) and adverse neonatal outc...